Hydrochloric Acid → HCID 59428371, compound

HRID 503953Notes

Reaction equation

HRID 503953 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([C:13]2[CH:18]=[CH:17][C:16]([S:19]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[CH:23]=3)(=[O:21])=[O:20])=[CH:15][C:14]=2[O:29][CH2:30][C:31](=[O:34])[NH:32][CH3:33])[CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[F:28][C:24]1[CH:23]=[C:22]([S:19]([C:16]2[CH:17]=[CH:18][C:13]([CH:10]3[CH2:11][CH2:12][NH:8][CH2:9]3)=[C:14]([CH:15]=2)[O:29][CH2:30][C:31]([NH:32][CH3:33])=[O:34])(=[O:21])=[O:20])[CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66877038HCID 66877038, compound

Product 1

HCID 59428371HCID 59428371, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3-[4-(3-Fluoro-benzenesulfonyl)-2-methylcarbamoylmethoxy-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester was deprotected using HCl in 1,4-dioxane following the procedure described in Example 13, to afford 2-[5-(3-Fluoro-benzenesulfonyl)-2-pyrrolidin-3-yl-phenoxy]-N-methyl-acetamide as a hydrochloride salt. MS (M+H)=393.

Sources & evidence

ORD record
ord-d3d56c65686f44b1b11af357bc595726
Source dataset
uspto-grants-2010_08
Patent number
US07776910B2

Reaction notes

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