Trifluoroacetic acid → HCID 59428418, compound

HRID 503960Notes

Reaction equation

HRID 503960 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([C:13]2[CH:18]=[CH:17][C:16]([S:19]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[CH:23]=3)(=[O:21])=[O:20])=[CH:15][C:14]=2[C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:32]([O:31][C:29](=[O:30])[C:14]1[CH:15]=[C:16]([S:19]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[CH:23]=2)(=[O:20])=[O:21])[CH:17]=[CH:18][C:13]=1[CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1)[CH3:33]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66876536HCID 66876536, compound

Product 1

HCID 59428418HCID 59428418, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-[2-Ethoxycarbonyl-4-(3-fluoro-benzenesulfonyl)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (71 mg, 0.149 mmol) was dissolved in 2 ml of CH2Cl2. TFA (0.5 ml) was added and the mixture was stirred for 4 hours. The solution was concentrated under reduced pressure to give 5-(3-Fluoro-benzenesulfonyl)-2-pyrrolidin-3-yl-benzoic acid ethyl ester, MS (M+H)=378.

Workup

  1. concentrationThe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-36cc75e1977f4416ab0bdab468640cc1
Source dataset
uspto-grants-2010_08
Patent number
US07776910B2

Reaction notes

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