Hydrochloric Acid → HCID 18412524, compound

HRID 50399Notes

Reaction equation

HRID 50399 reaction equation
[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([CH2:31]CC(OC)=O)[C:9]([C:11]1[CH:16]=[CH:15][N:14]2[C:17]([CH3:30])=[C:18]([CH2:20][CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]#[N:29])=[CH:24][CH:23]=3)[N:19]=[C:13]2[CH:12]=1)=[O:10].Cl.C(=O)([O-])[O-].[NH4+:42].[NH4+].[C:44]([O:47][CH2:48][CH3:49])(=[O:46])[CH3:45].C(O)C.N>C(O)C>[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([CH2:31][CH2:45][C:44]([O:47][CH2:48][CH3:49])=[O:46])[C:9]([C:11]1[CH:16]=[CH:15][N:14]2[C:17]([CH3:30])=[C:18]([CH2:20][CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28](=[NH:42])[NH2:29])=[CH:24][CH:23]=3)[N:19]=[C:13]2[CH:12]=1)=[O:10]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 517111Ammonium CarbonateHCID 184126013-Methyl-2-[2-(4-cyanophenyl)ethyl]-imidazo[1.2-a]pyridin-7-yl-carboxylic acid-n-(2-pyridyl)-n-(2-methoxycarbonylethyl)-amide-hydrochlorideHCID 86587043Ethyl acetate ethanol ammonia

Product 1

HCID 18412524HCID 18412524, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared analogously to Example 1 from 3-methyl-2-[2-(4-cyanophenyl)ethyl]imidazo[1,2-a]pyridin-7-yl-carboxylic acid-N-(2-pyridyl)-N-(2-methoxycarbonylethyl)amide hydrochloride and ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 53% of theory, C28H30N6O3 (498.59); Rf value: 0.42 (silica gel; ethyl acetate/ethanol/ammonia=50:45:5); EKA mass spectrum: (M+H)+=499; (M+2Na)++=272; (M+H+Na)++=261; (M+2H)++=250.

Sources & evidence

ORD record
ord-7ac71ec04e984905bd065676e817b09d
Source dataset
uspto-grants-2004_03
Patent number
US06710055B2

Reaction notes

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