Hydrochloric Acid → HCID 66661648, compound

HRID 504284Notes

Reaction equation

HRID 504284 reaction equation
O.[OH-].[Li+].[C:4]1([C:10]2[N:15]=[CH:14][C:13]([C:16]3([C:19]([O:21]CC)=[O:20])[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl>CO.O>[C:4]1([C:10]2[N:15]=[CH:14][C:13]([C:16]3([C:19]([OH:21])=[O:20])[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 66661635Ethyl 1-(6-phenylpyridin-3-yl)cyclopropanecarboxylate

Product 1

HCID 66661648HCID 66661648, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Lithium hydroxide, monohydrate (0.016 g, 0.37 mmol) was added to ethyl 1-(6-phenylpyridin-3-yl)cyclopropanecarboxylate (50.0 mg, 0.19 mmol) in methanol (1.5 mL) and water (0.5 mL). The mixture was stirred at room temperature for overnight, then was adjusted to be acidic (pH=5) with 1N HCl aqueous solution, and then was concentrated to give a crude product which was directly used in the reaction of the next step without further purification.

Workup

  1. concentrationwas concentrated

Sources & evidence

ORD record
ord-627d233647504449836e3d1b7d6a850a
Source dataset
uspto-grants-2010_08
Patent number
US07776874B2

Reaction notes

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