Potassium Carbonate → HCID 74928768, compound

HRID 504462Notes

Reaction equation

HRID 504462 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]2[NH:8][C:9](=[O:44])[C:10]3([CH:15]([C:16]4[CH:21]=[C:20]([C:22]#[C:23][Si](C)(C)C)[CH:19]=[CH:18][C:17]=4[O:28][CH2:29][C:30]4([CH3:34])[CH2:33][O:32][CH2:31]4)[CH2:14][C:13](=[O:35])[NH:12][CH:11]3[C:36]3[CH:41]=[C:40]([Cl:42])[CH:39]=[CH:38][C:37]=3[CH3:43])[C:5]2=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+]>CO>[Cl:1][C:2]1[CH:7]=[C:6]2[NH:8][C:9](=[O:44])[C:10]3([CH:15]([C:16]4[CH:21]=[C:20]([C:22]#[CH:23])[CH:19]=[CH:18][C:17]=4[O:28][CH2:29][C:30]4([CH3:34])[CH2:31][O:32][CH2:33]4)[CH2:14][C:13](=[O:35])[NH:12][CH:11]3[C:36]3[CH:41]=[C:40]([Cl:42])[CH:39]=[CH:38][C:37]=3[CH3:43])[C:5]2=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86632055HCID 86632055, compound

Product 1

HCID 74928768HCID 74928768, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of racemic (2′S,3S,4′R)-6-chloro-2′-(5-chloro-2-methyl-phenyl)-4′-[2-(3-methyl-oxetan-3-ylmethoxy)-5-trimethylsilanylethynyl-phenyl]spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione in methanol (5 mL) was added K2CO3 (100 mg). The mixture was stirred at room temperature for 2 h, purified by prep-HPLC to give the title compound as a white solid (2.5 mg).

Workup

  1. custompurified by prep-HPLC

Sources & evidence

ORD record
ord-bfc845a4cd4c4997814ebceebc85cd42
Source dataset
uspto-grants-2010_08
Patent number
US07776875B2

Reaction notes

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