反应详情

温度

100 °C

A mixture of 5-chloro-2-hydroxy-benzaldehyde (4.5 g, 29 mmol), toluene-4-sulfonic acid 3-methyl-oxetan-3-ylmethyl ester in Example 13c (6.4 g, 25 mmol) and K2CO3 (8 g, 58 mmol) in anhydrous N,N-dimethylformamide (40 mL) was heated at 100° C. for 1 h. Then the mixture was filtered and the filtrate was concentrated. The residue was dissolve in EtOAc (50 mL). The solution was washed with water, dried and concentrated to give title compound as a yellow oil (5.2 g).

1. filtrationThen the mixture was filtered
2. concentrationthe filtrate was concentrated
3. dissolutionThe residue was dissolve in EtOAc (50 mL)
4. washThe solution was washed with water
5. customdried
6. concentrationconcentrated