Hydrazine hydrate (1:1) → HCID 59428939, compound

HRID 504970Notes

Reaction equation

HRID 504970 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:14][CH2:15][CH2:16][NH:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([N+:25]([O-])=O)=[CH:21][CH:20]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].O.NN>CCO>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:14][CH2:15][CH2:16][NH:17][CH2:18][C:19]1[CH:20]=[CH:21][C:22]([NH2:25])=[CH:23][CH:24]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 59428940HCID 59428940, compound

Product 1

HCID 59428939HCID 59428939, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of the compound obtained in step d) (0.183 g, 0.382 mmol) in EtOH (20 cm3) and of FeO(OH) as catalyst (20 mg) was heated to 60° C. under N2 atmosphere. Then hydrazine hydrate (19.5 mg, 0.60 mmol) was added and the resulting mixture was stirred 18 h at RT. After filtration through celite the solvent was removed at the rotary evaporator to yield a yellow oil which was dried under reduced pressure. (0.112 g, 0.248 mmol, yield 65.0%).

Workup

  1. filtrationAfter filtration through celite the solvent
  2. customwas removed at the rotary evaporator
  3. customto yield a yellow oil which
  4. customwas dried under reduced pressure

Sources & evidence

ORD record
ord-8b17feddcbf44235b2077b7dd6095e71
Source dataset
uspto-grants-2010_08
Patent number
US07780952B2

Reaction notes

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