Water → HCID 86761159, compound

HRID 504974Notes

Reaction equation

HRID 504974 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]([C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH2:10][O:11][P:12](=[O:39])([OH:38])[O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20]C(=O)OCC1C2C=CC=CC=2C2C1=CC=CC=2)=[O:7])([CH3:4])([CH3:3])[CH3:2].O>N1CCCCC1>[NH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][O:13][P:12]([O:11][CH2:10][CH:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[C:40]([O:42][C:43]([CH3:45])([CH3:46])[CH3:44])=[O:41])([OH:39])=[O:38]

Participants

4

Reactant 2

HCID 962WaterHCID 68788338HCID 68788338, compound

Product 1

HCID 86761159HCID 86761159, compound

Reagents, catalysts & solvents 1

HCID 8082PiperidineSolvent

Procedure

3 g of tert-butyl 15-[(tert-butoxycarbonyl)amino]-1-(9H-fluoren-9-yl)-12-hydroxy-3-oxo-2,11,13-trioxa-4-aza-12-phosphahexadecan-16-oate 12-oxide are stirred in 0.62 ml of piperidine and 3 ml of water for 12 hours at ambient temperature. The reaction medium is filtered and the crystals obtained are washed twice with 50 ml of acetonitrile and then recrystallized from 100 ml of acetonitrile.

Workup

  1. filtrationThe reaction medium is filtered
  2. customthe crystals obtained
  3. washare washed twice with 50 ml of acetonitrile
  4. customrecrystallized from 100 ml of acetonitrile

Sources & evidence

ORD record
ord-f1aeeab0e4304c46a75b9274216f916f
Source dataset
uspto-grants-2010_08
Patent number
US07780953B2

Reaction notes

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