Hydrochloric Acid → HCID 66743468, compound

HRID 505158Notes

Reaction equation

HRID 505158 reaction equation
C(OC([N:8]1[CH2:36][CH2:35][N:11]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=3[C:18]([C:19]([N:21]3[CH2:26][CH2:25][CH:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[O:33][CH3:34])[CH2:23][CH2:22]3)=[O:20])=[C:10]2[CH2:9]1)=O)(C)(C)C.[ClH:37]>CO>[ClH:37].[CH3:34][O:33][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=1[CH:24]1[CH2:25][CH2:26][N:21]([C:19]([C:18]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N:11]3[CH2:35][CH2:36][NH:8][CH2:9][C:10]=23)=[O:20])[CH2:22][CH2:23]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59429634HCID 59429634, compound

Product 1

HCID 66743468HCID 66743468, compoundYield 99.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 0.085 g (0.17 mmol) 10-[4-(2-methoxy-phenyl)-piperidine-1-carbonyl]-3,4-dihydro-1H-pyrazino[1,2-a]indole-2-carboxylic acid tert-butyl ester and 1.4 ml of a 1.25 M solution of hydrochloric acid (1.7 mmol) in methanol was stirred for 15 min at 50° C. The reaction mixture was concentrated in vacuo to give the title compound (0.072 g, 97%) as a light yellow solid.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-9543c91472a843a0a522967994f085f7
Source dataset
uspto-grants-2010_08
Patent number
US07781436B2

Reaction notes

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