Methanesulfonyl chloride → HCID 24896491, compound

HRID 505291Notes

Reaction equation

HRID 505291 reaction equation
[F:1][C:2]([F:38])([F:37])[C:3]1[CH:4]=[C:5]([C@H:13]2[O:17][C:16](=[O:18])[N:15]([CH2:19][C:20]3[CH:25]=[C:24]([O:26][C:27]([F:30])([F:29])[F:28])[CH:23]=[CH:22][C:21]=3[NH:31][CH2:32][CH:33]([CH3:35])[CH3:34])[C@H:14]2[CH3:36])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[CH3:39][S:40](Cl)(=[O:42])=[O:41]>N1C=CC=CC=1.CN(C)C1C=CN=CC=1.CCOC(C)=O>[F:38][C:2]([F:1])([F:37])[C:3]1[CH:4]=[C:5]([C@H:13]2[O:17][C:16](=[O:18])[N:15]([CH2:19][C:20]3[CH:25]=[C:24]([O:26][C:27]([F:28])([F:29])[F:30])[CH:23]=[CH:22][C:21]=3[N:31]([CH2:32][CH:33]([CH3:34])[CH3:35])[S:40]([CH3:39])(=[O:42])=[O:41])[C@H:14]2[CH3:36])[CH:6]=[C:7]([C:9]([F:11])([F:10])[F:12])[CH:8]=1

Participants

6

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 24896195HCID 24896195, compound

Product 1

HCID 24896491HCID 24896491, compound

Reagents, catalysts & solvents 3

HCID 142844-(Dimethylamino)pyridineCatalystHCID 1049PyridineSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
65 °C

Procedure

To a solution of (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(isobutylamino)-5-(trifluoromethoxy)benzyl]-4-methyl-1,3-oxazolidin-2-one (9.2 mg, 0.0165 mmol) in pyridine (300 μL) was added methanesulfonyl chloride (100 μL, 1.29 mmol) and excess 4-dimethylaminopyridine. The reaction was stirred at 65° C. for 4 hours and then diluted with EtOAc (15 mL), and washed with 1 N HCl (2×10 mL) and brine (10 mL). The organic layer was dried over Na2SO4, filtered, and concentrated. Purification of the residue by PTLC (60% EtOAc/hexanes) N-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethoxy)phenyl]-N-isobutylmethanesulfonamide. Rf=0.25 (60% EtOAc/hexanes). LCMS=637.4 (M+1)+. 1H NMR (CDCl3, 500 MHz) δ 7.91 (s, 1H), 7.80 (s, 2H), 7.34-2.46 (m, 3H), 5.79-5.76 (m, 1H), 4.90-4.58 (m, 2H), 4.19-4.14 (m, 1H), 3.51-3.46 (m, 1H), 3.34-3.32 (m, 1H), 2.97 (m, 3H), 1.25 (m, 1H), 0.93-0.87 (m, 6H), 0.70-0.66 (m, 3H).

Workup

  1. washwashed with 1 N HCl (2×10 mL) and brine (10 mL)
  2. dry with materialThe organic layer was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customPurification of the residue by PTLC (60% EtOAc/hexanes) N-[2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4-(trifluoromethoxy)phenyl]-N-isobutylmethanesulfonamide

Sources & evidence

ORD record
ord-65285b0dbe36449dbe154d839a5ef566
Source dataset
uspto-grants-2010_08
Patent number
US07781426B2

Reaction notes

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