Hydrochloric Acid → HCID 11255315, compound

HRID 505445Notes

Reaction equation

HRID 505445 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[C:8]([C:15]([O:17]C)=[O:16])[N:9]([CH3:14])[C:10]2=[O:13])=[CH:5][CH:4]=1.[OH-].[K+].Cl>C(O)C>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[C:8]([C:15]([OH:17])=[O:16])[N:9]([CH3:14])[C:10]2=[O:13])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 11209508HCID 11209508, compound

Product 1

HCID 11255315HCID 11255315, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The ester 5 (180 mg, 0.56 mmol) was suspended in ethanol (5 ml). 1M KOH (1 ml) was added and the resulting mixture heated at 80 C. A homogenous solution was obtained within minutes. After 2 h, the reaction mixture was cooled and acidified with 1M HCl. The ethanol was removed under reduced pressure and water was added to the residue. The mixture was filtered and the residue washed well with water and dried to give the acid 6.

Workup

  1. temperaturethe resulting mixture heated at 80 C
  2. customA homogenous solution was obtained within minutes
  3. temperaturethe reaction mixture was cooled
  4. customThe ethanol was removed under reduced pressure and water
  5. additionwas added to the residue
  6. filtrationThe mixture was filtered
  7. washthe residue washed well with water
  8. customdried

Sources & evidence

ORD record
ord-0aa17df66e6c421493bd57c35290c8dc
Source dataset
uspto-grants-2010_08
Patent number
US07781457B2

Reaction notes

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