Dimethylamine → HCID 11371655, compound

HRID 505448Notes

Reaction equation

HRID 505448 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=3)[C:11](=[O:20])[N:10]([CH3:21])[C:9]=2[C:22]([OH:24])=O)[CH:5]=[CH:6][CH:7]=1.[CH3:25][NH:26][CH3:27]>ClC(Cl)C.CN(C1C=CN=CC=1)C>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=3)[C:11](=[O:20])[N:10]([CH3:21])[C:9]=2[C:22]([N:26]([CH3:27])[CH3:25])=[O:24])[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 674DimethylamineHCID 11255888HCID 11255888, compound

Product 1

HCID 11371655HCID 11371655, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 63651,1-DichloroethaneSolvent

Procedure

The acid chloride of 11 (80 mg, 0.mmol mmol) was added to a solution of excess dimethylamine in dichloroethane containing a catalytic amount of DMAP at room temperature. After stirring for 30 min the reaction mixture was washed with 1M HCl then brine. Drying (Na2SO4) and concentration gave the amide 12.

Workup

  1. washwas washed with 1M HCl
  2. customDrying
  3. concentration(Na2SO4) and concentration

Sources & evidence

ORD record
ord-e9a7012afe254fd5aec6ca9187b69441
Source dataset
uspto-grants-2010_08
Patent number
US07781457B2

Reaction notes

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