反应详情

温度

90 °C

A mixture of 2-benzyloxy-5-bromobenzaldehyde (0.10 mol), malonic acid (15.0 g), and piperidine (2.0 ml) in 150 ml of pyridine was first heated at 90° C. for 90 min and subsequently refluxed for 0.5 hrs. After cooling to room temperature, the reaction was poured on a mixture of ice (1 kg) and concentrated aqueous hydrochloric acid (250 ml). The solid material that precipitated after stirring for 2 hrs. was collected by suction and recrystallized from a minimum of boiling methanol.

1. temperaturesubsequently refluxed for 0.5 hrs
2. temperatureAfter cooling to room temperature
3. customThe solid material that precipitated
4. customwas collected by suction
5. customrecrystallized from a minimum of boiling methanol