Lithium Hydroxide → HCID 178509970, compound

HRID 505916Notes

Reaction equation

HRID 505916 reaction equation
FC(F)(F)C([NH:5][CH2:6][C:7]1[N:8]([C:12]2[CH:13]=[C:14]([C:18]3[NH:19][C:20]4[C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=[CH:23][C:21]=4[N:22]=3)[CH:15]=[CH:16][CH:17]=2)[CH:9]=[CH:10][CH:11]=1)=O.[OH-].[Li+]>O>[NH2:5][CH2:6][C:7]1[N:8]([C:12]2[CH:13]=[C:14]([C:18]3[NH:19][C:20]4[C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=[CH:23][C:21]=4[N:22]=3)[CH:15]=[CH:16][CH:17]=2)[CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 178513615HCID 178513615, compound

Product 1

HCID 178509970HCID 178509970, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

1.0 g (2.3 mmol) of the compound from Example 32 was dissolved in 100 ml of water and admixed with 0.56 g (23.4 mmol) of lithium hydroxide, dissolved in 20 ml of water. The entire mixture was stirred at room temperature for 90 minutes. The organic solvent was subsequently removed under reduced pressure and the resulting aqueous phase was neutralized carefully using dilute hydrochloric acid. The resulting precipitate was filtered off with suction. This gave 0.55 g of the product.

Workup

  1. customThe organic solvent was subsequently removed under reduced pressure
  2. filtrationThe resulting precipitate was filtered off with suction

Sources & evidence

ORD record
ord-59798fe5855b4e0a8cd710964e3525e8
Source dataset
uspto-grants-2010_08
Patent number
US07781596B1

Reaction notes

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