Dimethylformamide dimethyl acetal → HCID 68462245, compound

HRID 505956Notes

Reaction equation

HRID 505956 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH2:12])(=[O:11])=[O:10])=[CH:5][C:4]=1[CH2:13][OH:14].CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]=[CH:17][N:18]([CH3:20])[CH3:19])(=[O:11])=[O:10])=[CH:5][C:4]=1[CH2:13][OH:14]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 587888603-(Hydroxymethyl)-4-methoxybenzene-1-sulfonamide

Product 1

HCID 68462245HCID 68462245, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

The mixture consisting of 1 g of 4-methoxy-3-hydroxymethylphenylsulfonamide, 0.66 g of dimethylformamide dimethyl acetal and 5 ml of dimethylformamide is stirred at 80° C. for one hour and then concentrated in vacuo. The residue is an oil which gradually solidifies and which is used without further purification for the following chlorination.

Workup

  1. concentrationconcentrated in vacuo
  2. customwhich is used without further purification for the following chlorination

Sources & evidence

ORD record
ord-43f1e0a8ba7741e694c4a94c3e348858
Source dataset
uspto-grants-2010_08
Patent number
US07781613B2

Reaction notes

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