Piperidine → 1-(5-Benzofuranylmethyl)piperidine

HRID 506192Notes

Reaction equation

HRID 506192 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]=O)=[CH:9][C:4]=2[CH:3]=[CH:2]1.[NH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][N:12]3[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

4

Reactant 3

HCID 8082PiperidineHCID 27738751-Benzofuran-5-carbaldehydeHCID 5049666Sodium triacetoxyborohydride

Product 1

HCID 684676921-(5-Benzofuranylmethyl)piperidine

Procedure

1-Benzofuran-5-carbaldehyde was treated with piperidine and sodium triacetoxyborohydride under the standard reductive amination protocol to provide 1-(5-benzofuranylmethyl)piperidine.

Sources & evidence

ORD record
ord-4997d495a46e48b696d881aa799abc90
Source dataset
uspto-grants-2010_08
Patent number
US07781591B2

Reaction notes

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