Hydrochloric Acid → (1R-trans)-2-(3,4-Difluorophenyl)-N-methylcyclopropanamine, Hydrochloride

HRID 50643Notes

Reaction equation

HRID 50643 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@@H:9]2[CH2:11][C@H:10]2[N:12](C)[C:13](=O)C)[CH:5]=[CH:6][C:7]=1[F:8].[ClH:17]>>[ClH:17].[F:1][C:2]1[CH:3]=[C:4]([C@@H:9]2[CH2:11][C@H:10]2[NH:12][CH3:13])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 69886212(1r-trans)-n-[2-(3,4-Difluorophenyl)cyclopropyl]-n-methylacetamide

Product 1

HCID 131724387(1R-trans)-2-(3,4-Difluorophenyl)-N-methylcyclopropanamine, Hydrochloride

Procedure

A solution of the product from step b) (443 mg) in 4M HCl (10 ml) was refluxed for 8 h. The solvent was removed in vacuo to give the sub-title compound (357 mg).

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-7bc1f35465134208be37a322434d9189
Source dataset
uspto-grants-2004_03
Patent number
US06713483B1

Reaction notes

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