反应详情

3-Hydroxyphenylacetylene (237 mg, 2 mmol) was heated with 2-bromoethylmethylether (0.23 mL, 2.4 mmol) and potassium carbonate (322 mg, 2.4 mmol) in acetone (5 mL) to 110° C. in a microwave oven (CEM Discover) for 45 minutes. Water (1 mL) was added to the mixture and the whole was extracted with dichloromethane (2×25 mL). The combined organics were dried over MgSO4, filtered and concentrated in vacuo to afford a brown oil. The oil was purified by column chromatography (SiO2, dichloromethane) to afford 3-(2-methoxyethoxy)phenylacetylene as a colourless oil (247 mg, 70% yield).

1. extractionthe whole was extracted with dichloromethane (2×25 mL)
2. dry with materialThe combined organics were dried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customto afford a brown oil
6. customThe oil was purified by column chromatography (SiO2, dichloromethane)