Potassium Carbonate → HCID 16679702, compound

HRID 506669Notes

Reaction equation

HRID 506669 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:12]2[N:11]3[CH2:15][CH2:16][CH2:17][NH:18][C:19](=[O:20])[C:10]3=[CH:9][C:8]=2[CH:7]=1.[NH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1.C(=O)([O-])[O-].[K+].[K+]>>[N:21]1([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:14]=[CH:13][C:12]3[N:11]4[CH2:15][CH2:16][CH2:17][NH:18][C:19](=[O:20])[C:10]4=[CH:9][C:8]=3[CH:7]=2)[CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 684636919-(3-Chloro-propoxy)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one

Product 1

HCID 16679702HCID 16679702, compoundYield 50%

Procedure

The title compound was synthesized in analogy to example 2, from 9-(3-chloro-propoxy)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one, pyrrolidine (commercially available) and potassium carbonate, to give the desired product as a light yellow solid (50%).

Sources & evidence

ORD record
ord-128ebfcd1e824d1180a5266fa7e05b66
Source dataset
uspto-grants-2010_08
Patent number
US07786109B2

Reaction notes

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