Sodium hydride → HCID 68462725, compound

HRID 506737Notes

Reaction equation

HRID 506737 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:18]=[CH:17][C:16]3[N:15]4[CH2:19][CH2:20][CH2:21][NH:22][C:23](=[O:24])[C:14]4=[CH:13][C:12]=3[CH:11]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:26][CH:27]1[CH2:29][CH2:28]1.[H-].[Na+]>>[CH:27]1([CH2:26][N:22]2[CH2:21][CH2:20][CH2:19][N:15]3[C:16]4[CH:17]=[CH:18][C:10]([O:9][CH2:8][CH2:7][CH2:6][N:1]5[CH2:5][CH2:4][CH2:3][CH2:2]5)=[CH:11][C:12]=4[CH:13]=[C:14]3[C:23]2=[O:24])[CH2:29][CH2:28]1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 81503BromomethylcyclopropaneHCID 16679702HCID 16679702, compound

Product 1

HCID 68462725HCID 68462725, compoundYield 29%

Procedure

The title compound was synthesized in analogy to example 17, from 9-(3-pyrrolidin-1-yl-propoxy)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one (example 16), 1-(bromomethyl)cyclopropane and sodium hydride, to give the desired product as a white solid (29%).

Sources & evidence

ORD record
ord-89af06eacd4248138d65597b99be3de0
Source dataset
uspto-grants-2010_08
Patent number
US07786109B2

Reaction notes

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