Sodium hydride → HCID 68463221, compound

HRID 506763Notes

Reaction equation

HRID 506763 reaction equation
[Br:1][C:2]1[C:3]([O:17][CH:18]2[CH2:23][CH2:22][N:21]([CH:24]([CH3:26])[CH3:25])[CH2:20][CH2:19]2)=[CH:4][C:5]2[CH:6]=[C:7]3[C:14](=[O:15])[NH:13][CH2:12][C@@H:11]([CH3:16])[N:8]3[C:9]=2[CH:10]=1.[H-].[Na+].Br[CH2:30][CH:31]1[CH2:33][CH2:32]1>>[Br:1][C:2]1[C:3]([O:17][CH:18]2[CH2:23][CH2:22][N:21]([CH:24]([CH3:26])[CH3:25])[CH2:20][CH2:19]2)=[CH:4][C:5]2[CH:6]=[C:7]3[C:14](=[O:15])[N:13]([CH2:30][CH:31]4[CH2:33][CH2:32]4)[CH2:12][C@@H:11]([CH3:16])[N:8]3[C:9]=2[CH:10]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 81503BromomethylcyclopropaneHCID 16679129HCID 16679129, compound

Product 1

HCID 68463221HCID 68463221, compound

Procedure

The title compound was synthesized in analogy to example 17, from (R)-7-bromo-8-(1-isopropyl-piperidin-4-yloxy)-4-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 93), sodium hydride and 1-(bromomethyl)cyclopropane, to give the product as a white solid (55%).

Sources & evidence

ORD record
ord-4d41ba68a91543e5a30ac1c13d014ef4
Source dataset
uspto-grants-2010_08
Patent number
US07786109B2

Reaction notes

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