Potassium Carbonate → HCID 68467842, compound

HRID 506795Notes

Reaction equation

HRID 506795 reaction equation
[Cl:1][C:2]1[C:7]([F:8])=[CH:6][N:5]=[C:4]2[N:9]([S:35]([C:38]3[CH:43]=[CH:42][C:41]([CH3:44])=[CH:40][CH:39]=3)(=[O:37])=[O:36])[C:10]([C:12]3[C:16]4=[N:17][C:18]([O:23][CH3:24])=[C:19]([O:21][CH3:22])[CH:20]=[C:15]4[N:14]([CH2:25][CH2:26][CH2:27][N:28]4[CH2:33][CH2:32]N(C)[CH2:30][CH2:29]4)[CH:13]=3)=[CH:11][C:3]=12.ClC1C(F)=CN=C2N(S(C3C=CC(C)=CC=3)(=O)=O)C(C3C4=NC(OC)=C([O:65]C)C=C4N(CC(I)C)C=3)=CC=12.C(=O)([O-])[O-].[K+].[K+].CN1CCNCC1>C(#N)C>[Cl:1][C:2]1[C:7]([F:8])=[CH:6][N:5]=[C:4]2[N:9]([S:35]([C:38]3[CH:43]=[CH:42][C:41]([CH3:44])=[CH:40][CH:39]=3)(=[O:37])=[O:36])[C:10]([C:12]3[C:16]4=[N:17][C:18]([O:23][CH3:24])=[C:19]([O:21][CH3:22])[CH:20]=[C:15]4[N:14]([CH2:25][CH2:26][CH2:27][N:28]4[CH2:33][CH2:32][O:65][CH2:30][CH2:29]4)[CH:13]=3)=[CH:11][C:3]=12

Participants

6

Reactant 4

HCID 11430Potassium CarbonateHCID 531671-MethylpiperazineHCID 68468936HCID 68468936, compoundHCID 68470274HCID 68470274, compound

Product 1

HCID 68467842HCID 68467842, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3-[4-Chloro-5-fluoro-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-5,6-dimethoxy-1-[3-(4-methylpiperazin-1-yl)propyl]-1H-pyrrolo[3,2-b]pyridine can be prepared as in example 2, stage 2(c), but starting with 0.300 g of 3-[4-chloro-5-fluoro-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-1-(2-iodopropyl)-5,6-dimethoxy-1H-pyrrolo[3,2-b]pyridine, 0.068 g of potassium carbonate and 0.090 g of 1-methylpiperazine in 50 cm3 of acetonitrile. 0.192 g of 3-[4-chloro-5-fluoro-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-5,6-dimethoxy-1-(3-morpholin-4-ylpropyl)-1H-pyrrolo[3,2-b]pyridine is obtained as a resin with the following characteristics:

Sources & evidence

ORD record
ord-763293dafe394210abbb419b92fd8912
Source dataset
uspto-grants-2010_08
Patent number
US07786114B2

Reaction notes

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