反应详情

To a solution of 0.11 g of cyclopropyl-[2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]amine in 20 cm3 of methanol, at a temperature in the region of 20° C., is added 1 cm3 of 5N potassium hydroxide. The reaction medium is refluxed for 24 hours. After cooling, the reaction medium is concentrated under reduced pressure. The residue obtained is taken up in 20 cm3 of water. The solid formed is filtered off on a sinter funnel. The solid obtained is taken up in 80 cm3 of dichloromethane and 3 cm3 of water. The organic phase is dried over magnesium sulfate, filtered and then concentrated under reduced pressure to give 0.075 g of cyclopropyl-[2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]amine with the following characteristics:

1. temperatureThe reaction medium is refluxed for 24 hours
2. temperatureAfter cooling
3. concentrationthe reaction medium is concentrated under reduced pressure
4. customThe residue obtained
5. customThe solid formed
6. filtrationis filtered off on a sinter funnel
7. customThe solid obtained
8. dry with materialThe organic phase is dried over magnesium sulfate
9. filtrationfiltered
10. concentrationconcentrated under reduced pressure