Potassium Hydroxide → HCID 68467161, 화합물

HRID 506800노트

반응식

HRID 506800 반응식
[CH:1]1([NH:4][CH2:5][C:6]2[CH:11]=[CH:10][N:9]=[C:8]3[N:12](S(C4C=CC(C)=CC=4)(=O)=O)[C:13]([C:15]4[C:19]5=[N:20][C:21]([O:26][CH3:27])=[C:22]([O:24][CH3:25])[CH:23]=[C:18]5[N:17]([CH3:28])[CH:16]=4)=[CH:14][C:7]=23)[CH2:3][CH2:2]1.[OH-].[K+]>CO.O.ClCCl>[CH:1]1([NH:4][CH2:5][C:6]2[CH:11]=[CH:10][N:9]=[C:8]3[NH:12][C:13]([C:15]4[C:19]5=[N:20][C:21]([O:26][CH3:27])=[C:22]([O:24][CH3:25])[CH:23]=[C:18]5[N:17]([CH3:28])[CH:16]=4)=[CH:14][C:7]=23)[CH2:2][CH2:3]1

참가 물질

6

반응물 2

HCID 14797Potassium HydroxideHCID 68468463cyclopropyl-[2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]-amine

생성물 1

HCID 68467161HCID 68467161, 화합물수율 96%

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매2회HCID 6344Dichloromethane용매

실험 절차

To a solution of 0.11 g of cyclopropyl-[2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]amine in 20 cm3 of methanol, at a temperature in the region of 20° C., is added 1 cm3 of 5N potassium hydroxide. The reaction medium is refluxed for 24 hours. After cooling, the reaction medium is concentrated under reduced pressure. The residue obtained is taken up in 20 cm3 of water. The solid formed is filtered off on a sinter funnel. The solid obtained is taken up in 80 cm3 of dichloromethane and 3 cm3 of water. The organic phase is dried over magnesium sulfate, filtered and then concentrated under reduced pressure to give 0.075 g of cyclopropyl-[2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl]amine with the following characteristics:

후처리

  1. temperatureThe reaction medium is refluxed for 24 hours
  2. temperatureAfter cooling
  3. concentrationthe reaction medium is concentrated under reduced pressure
  4. customThe residue obtained
  5. customThe solid formed
  6. filtrationis filtered off on a sinter funnel
  7. customThe solid obtained
  8. dry with materialThe organic phase is dried over magnesium sulfate
  9. filtrationfiltered
  10. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-9d43680dc2214d83953f383abd33923d
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786114B2

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