反应详情

To a solution of 0.07 g of 2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-carbaldehyde in 7 cm3 of methanol and 20 cm3 of dichloromethane, at a temperature in the region of 20° C., is added 0.012 g of sodium borohydride. The reaction medium is stirred at room temperature for 24 hours. The reaction medium is concentrated under reduced pressure. The residue obtained is taken up in 10 cm3 of water and 20 cm3 of ethyl acetate. After separation of the phases by settling, the organic phase is dried over magnesium sulfate, filtered and then concentrated under reduced pressure. 0.045 g of [2-(5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]methanol is obtained with the following characteristics:

1. concentrationThe reaction medium is concentrated under reduced pressure
2. customThe residue obtained
3. customAfter separation of the phases
4. dry with materialthe organic phase is dried over magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure