Hydrochloric Acid → N-Methyl-N-(piperidin-4-yl)acetamide

HRID 506858Notes

Reaction equation

HRID 506858 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([C:16](=[O:18])[CH3:17])[CH3:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CCOC(C)=O>[CH3:15][N:14]([CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[C:16](=[O:18])[CH3:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22061331tert-Butyl 4-[acetyl(methyl)amino]piperidine-1-carboxylate

Product 1

HCID 21468403N-Methyl-N-(piperidin-4-yl)acetamide

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4-(acetyl-methyl-amino)-piperidine-1-carboxylic acid tert-butyl ester (525 mg, 2.05 mmol) in AcOEt (5 ml) was added HCl 3N (4 ml). The reaction mixture was stirred at RT for 16 hrs. Solvent were removed under reduced pressure to gine the expected N-methyl-N-piperidin-4-yl-acetamide as its hydrochloride salt (395 mg, quant.).

Workup

  1. customSolvent were removed under reduced pressure

Sources & evidence

ORD record
ord-0dd63d0f2e3c4e5e9183e378ca92637d
Source dataset
uspto-grants-2010_08
Patent number
US07786121B2

Reaction notes

Loading…