1-(4-Fluorophenyl)piperazine → 3-ethyl-3-{4-[4-(4-fluorophenyl)-piperazin-1-yl]-butyl}-1,3-dihydro-2H-indol-2-one

HRID 506923Notes

Reaction equation

HRID 506923 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][C:6]1([CH2:16][CH3:17])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][C:7]1=[O:15].[F:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:21][CH:20]=1>>[CH2:16]([C:6]1([CH2:5][CH2:4][CH2:3][CH2:2][N:28]2[CH2:27][CH2:26][N:25]([C:22]3[CH:21]=[CH:20][C:19]([F:18])=[CH:24][CH:23]=3)[CH2:30][CH2:29]2)[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][C:7]1=[O:15])[CH3:17]

Participants

3

Reactant 2

HCID 752601-(4-Fluorophenyl)piperazineHCID 670406333-(4-Chlorobutyl)-3-ethyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 248541873-ethyl-3-{4-[4-(4-fluorophenyl)-piperazin-1-yl]-butyl}-1,3-dihydro-2H-indol-2-one

Procedure

The title compound is prepared according to process H by applying processing method 1 starting from 3-(4-chlorobutyl)-3-ethyl-1,3-dihydro-2H-indol-2-one and 1-(4-fluorophenyl)-piperazine.

Sources & evidence

ORD record
ord-5d58094e2c06489c93b3f9ec0962c4fb
Source dataset
uspto-grants-2010_08
Patent number
US07786129B2

Reaction notes

Loading…