Hydrochloric Acid → HCID 11542083, compound

HRID 507118Notes

Reaction equation

HRID 507118 reaction equation
[ClH:1].[F:2][C:3]([F:46])([F:45])[C:4]1[CH:5]=[C:6]([CH:38]=[C:39]([C:41]([F:44])([F:43])[F:42])[CH:40]=1)[CH2:7][N:8]([C@H:15]1[CH2:21][CH2:20][CH2:19][N:18]([CH2:22][C:23]2[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=2)[C:17]2[CH:29]=[C:30]([C:34]([F:37])([F:36])[F:35])[C:31]([CH3:33])=[CH:32][C:16]1=2)[C:9]1[N:10]=[N:11][N:12]([CH3:14])[N:13]=1>C(OCC)C>[ClH:1].[F:46][C:3]([F:2])([F:45])[C:4]1[CH:5]=[C:6]([CH:38]=[C:39]([C:41]([F:42])([F:43])[F:44])[CH:40]=1)[CH2:7][N:8]([C@H:15]1[CH2:21][CH2:20][CH2:19][N:18]([CH2:22][C:23]2[CH:24]=[CH:25][N:26]=[CH:27][CH:28]=2)[C:17]2[CH:29]=[C:30]([C:34]([F:35])([F:36])[F:37])[C:31]([CH3:33])=[CH:32][C:16]1=2)[C:9]1[N:10]=[N:11][N:12]([CH3:14])[N:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11542084HCID 11542084, compound

Product 1

HCID 11542083HCID 11542083, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

Add 1.0 N HCl in ethyl ether (0.0500 mL) to a solution of (S)-(3,5-Bis-trifluoromethyl-benzyl)-(7-methyl-1-pyridin-4-ylmethyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-(2-methyl-2H-tetrazol-5-yl)-amine (0.0230 mg, 0.0357 mmole) in ethyl ether (0.500 mL), stir for 10 minutes. Evaporate the solvent to provide the title compound. MS (ES+): 644 (M+H).

Workup

  1. customEvaporate the solvent

Sources & evidence

ORD record
ord-d0dfe37f8f25430fa2e476d3d07d72ea
Source dataset
uspto-grants-2010_08
Patent number
US07786108B2

Reaction notes

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