Hydrochloric Acid → HCID 86615664, compound

HRID 507160Notes

Reaction equation

HRID 507160 reaction equation
[F:1][C:2]([F:43])([F:42])[C:3]1[CH:4]=[C:5]([CH:35]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:37]=1)[CH2:6][N:7]([C@H:14]1[CH2:20][CH2:19][CH2:18][N:17]([CH2:21][CH:22]2[CH2:24][CH2:23]2)[C:16]2[C:25]([CH3:34])=[C:26]([C:30]([F:33])([F:32])[F:31])[C:27]([CH3:29])=[CH:28][C:15]1=2)[C:8]1[N:9]=[N:10][N:11]([CH3:13])[N:12]=1.[ClH:44]>C(OCC)C>[ClH:44].[F:43][C:2]([F:1])([F:42])[C:3]1[CH:4]=[C:5]([CH:35]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:37]=1)[CH2:6][N:7]([C@H:14]1[CH2:20][CH2:19][CH2:18][N:17]([CH2:21][CH:22]2[CH2:24][CH2:23]2)[C:16]2[C:25]([CH3:34])=[C:26]([C:30]([F:31])([F:32])[F:33])[C:27]([CH3:29])=[CH:28][C:15]1=2)[C:8]1[N:9]=[N:10][N:11]([CH3:13])[N:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86615665HCID 86615665, compound

Product 1

HCID 86615664HCID 86615664, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

Dissolve (S)-(3,5-Bis-trifluoromethyl-benzyl)-(1-cyclopropylmethyl-7,9-dimethyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-(2-methyl-2H-tetrazol-5-yl)-amine (Example 148) (0.0210 g, 0.0338 mmol) in ethyl ether (0.5 mL). Add HCl in ether (1.0 N, 0.0338 mL). Evaporate the solvent and then triturate the residue with hexane to provide an off-white powder. MS (ES+): 621 (M+H).

Workup

  1. customEvaporate the solvent
  2. customtriturate the residue with hexane
  3. customto provide an off-white powder

Sources & evidence

ORD record
ord-2cc004ce995d466eafd6d184d437e236
Source dataset
uspto-grants-2010_08
Patent number
US07786108B2

Reaction notes

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