1-Heptanamine → HCID 68467487, compound

HRID 507201Notes

Reaction equation

HRID 507201 reaction equation
[O:1]([CH2:8][C:9]1[N:13]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=2)[C:12]2[CH:26]=[CH:27][C:28]([C:30]([OH:32])=O)=[CH:29][C:11]=2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC(C)N=C=NC(C)C.[CH2:42]([NH2:49])[CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH3:48]>C1COCC1>[CH2:42]([NH:49][C:30]([C:28]1[CH:27]=[CH:26][C:12]2[N:13]([CH2:14][C:15]3[CH:16]=[CH:17][C:18]([O:21][C:22]([F:23])([F:24])[F:25])=[CH:19][CH:20]=3)[C:9]([CH2:8][O:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[N:10][C:11]=2[CH:29]=1)=[O:32])[CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH3:48]

Participants

5

Reactant 3

HCID 81271-HeptanamineHCID 12734DiisopropylcarbodiimideHCID 684638462-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid

Product 1

HCID 68467487HCID 68467487, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.16 mmol of 2-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid were dissolved in 1 ml THF with 1 eq. DIC. After 15 min 1.5 eq of heptylamine were added and the reaction stirred at room temperature for 16 h. The crude material was purified via reversed phase preparative HPLC. MS(ISP): 540.3 (M+H)+.

Workup

  1. customThe crude material was purified via reversed phase preparative HPLC

Sources & evidence

ORD record
ord-989f7d2c7f9347cea1f15f9b26b9e5d2
Source dataset
uspto-grants-2010_08
Patent number
US07786128B2

Reaction notes

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