Trimethylsilyl isocyanate → HCID 59434054, compound

HRID 507395Notes

Reaction equation

HRID 507395 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]([CH2:14][C:15]([N:17]1[CH2:21][C:20](=[O:22])[N:19]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=2[CH3:30])[CH2:18]1)=[O:16])[C:5](=[O:13])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[CH:7]=1.C[Si]([N:35]=[C:36]=[O:37])(C)C>C1COCC1>[Cl:12][C:8]1[CH:7]=[C:6]([CH:11]=[CH:10][CH:9]=1)[C:5]([N:4]([CH2:14][C:15]([N:17]1[CH2:21][C:20](=[O:22])[N:19]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=2[CH3:30])[CH2:18]1)=[O:16])[CH2:3][CH2:2][NH:1][C:36]([NH2:35])=[O:37])=[O:13]

Participants

4

Reactant 2

HCID 70696Trimethylsilyl isocyanateHCID 59434015HCID 59434015, compound

Product 1

HCID 59434054HCID 59434054, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of N-(2-Amino-ethyl)-3-chloro-N-{2-[3-(3-chloro-2-methyl-phenyl)-4-oxo-imidazolidin-1-yl]-2-oxo-ethyl}-benzamide (80 mg, 0.16 mmol, 1 eq), Trimethylsilyl isocyanate (0.027 ml, 0.19 mmol, 1.2 eq), in THF (1 ml) was stirred at room temperature overnight. It was purified with HPLC to give the desired product. LCMS observed for (M+H)+: 492.1

Workup

  1. customIt was purified with HPLC

Sources & evidence

ORD record
ord-226235d422a245f5afd98d481db34d96
Source dataset
uspto-grants-2010_08
Patent number
US07786157B2

Reaction notes

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