反应详情

N-bromosuccinimide (33.8 g, 0.19 mmol) followed by perchloric acid (0.19 g, 0.002 mol) were added to a solution of 2-(thiophen-3-yl)ethanol )24.3 g, 0.19 mol) in carbon tetrachloride (250 mL) in a flask wrapped with aluminum foil at rt. The mixture was stirred in the dark at rt overnight and then potassium carbonate (40 g) was added. After stirring at rt for 1 h the mixture was filtered through Celite and washed with diethyl ether. The solvent was removed in vacuo and the product purified by flash chromatography eluting with ethyl acetate/hexane ((1:3) to give the title compound as an oil (25 g, 64%).

1. stirringAfter stirring at rt for 1 h the mixture
2. filtrationwas filtered through Celite
3. washwashed with diethyl ether
4. customThe solvent was removed in vacuo
5. customthe product purified by flash chromatography
6. washeluting with ethyl acetate/hexane ((1:3)