Hydrochloric Acid → HCID 178454725, compound

HRID 507842Notes

Reaction equation

HRID 507842 reaction equation
C[O:2][C:3](=[O:14])[C:4]([C@H:7]1[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9][CH2:8]1)([CH3:6])[CH3:5].[OH-].[Li+].Cl>CO>[OH:13][C@@H:10]1[CH2:9][CH2:8][C@H:7]([C:4]([CH3:6])([CH3:5])[C:3]([OH:14])=[O:2])[CH2:12][CH2:11]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 178500376HCID 178500376, compound

Product 1

HCID 178454725HCID 178454725, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.200 g of 2-(cis-4-hydroxy-cyclohexyl)-2-methyl-propionic acid methyl ester are dissolved in 4 ml of methanol. 4 ml of a 1M aqueous lithium hydroxide solution are added and the mixture is stirred for 16 hours at room temperature. The reaction mixture is then neutralised with 1M HCl and concentrated by evaporation. The title compound is identified from the residue by means of flash chromatography (SiO2 60F) based on its Rf value.

Workup

  1. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-fcb36772450f438f8efe163f43561ed0
Source dataset
uspto-grants-2010_08
Patent number
US07786307B2

Reaction notes

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