Hydrochloric Acid → HCID 178474958, compound

HRID 507850Notes

Reaction equation

HRID 507850 reaction equation
C[O:2][C:3](=[O:17])[C:4]([C@H:7]1[CH2:12][CH2:11][C@H:10]([NH:13][C:14](=[O:16])[CH3:15])[CH2:9][CH2:8]1)([CH3:6])[CH3:5].[OH-].[Li+].Cl>CO>[C:14]([NH:13][C@H:10]1[CH2:11][CH2:12][C@H:7]([C:4]([CH3:6])([CH3:5])[C:3]([OH:17])=[O:2])[CH2:8][CH2:9]1)(=[O:16])[CH3:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 178500374HCID 178500374, compound

Product 1

HCID 178474958HCID 178474958, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.200 g of trans-2-(4-acetylamino-cyclohexyl)-2-methyl-propionic acid methyl ester are dissolved in 4 ml of methanol. 4 ml of a 1M aqueous lithium hydroxide solution are added and the mixture is stirred for 16 hours at room temperature. The reaction mixture is neutralised with 1M HCl and extracted with ethyl acetate (3×50 ml)—the combined organic phases are concentrated by evaporation. The title compound is identified from the residue by means of flash chromatography (SiO2 60F) based on its Rf value.

Workup

  1. extractionextracted with ethyl acetate (3×50 ml)—the combined organic phases
  2. concentrationare concentrated by evaporation

Sources & evidence

ORD record
ord-ed6f2dd3c9d24c7cb2e110ce871abc3b
Source dataset
uspto-grants-2010_08
Patent number
US07786307B2

Reaction notes

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