Water → Trimethyl(2,3,2'-trifluoro-4'-iodobiphenyl-4-yl)silane

HRID 507898Notes

Reaction equation

HRID 507898 reaction equation
[Li]CCCC.Br[C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([Si:19]([CH3:22])([CH3:21])[CH3:20])=[C:15]([F:23])[C:14]=2[F:24])=[C:9]([F:25])[CH:8]=1.[I:26]CCI.O>C1COCC1.C(OC)(C)(C)C>[CH3:20][Si:19]([CH3:22])([CH3:21])[C:16]1[CH:17]=[CH:18][C:13]([C:10]2[CH:11]=[CH:12][C:7]([I:26])=[CH:8][C:9]=2[F:25])=[C:14]([F:24])[C:15]=1[F:23]

Participants

7

Reactant 4

HCID 962WaterHCID 122241,2-DiiodoethaneHCID 11462508(4'-Bromo-2,3,2'-trifluorobiphenyl-4-yl)trimethylsilaneHCID 178418339Butyllithium

Product 1

HCID 11304300Trimethyl(2,3,2'-trifluoro-4'-iodobiphenyl-4-yl)silaneYield 84%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 15413tert-Butyl methyl etherSolvent

Procedure

30 ml (48 mmol) of 1.6 M BuLi are added dropwise at −78° C. to a solution of 15.8 g (44 mmol) of 7 in 132 ml of dry THF. After 15 minutes, 16 g (57.2 mmol) of 1,2-diiodoethane are added as solid, and the mixture is allowed to warm to room temperature over the course of 1 hour. Water and methyl tert-butyl ether are subsequently added. The organic phase is washed with water, sat. Na2S2O5 and sat. NaCl, dried over MgSO4 and filtered through SiO2. The solvent is removed under reduced pressure, petroleum ether is added to the oily residue, and the product is recrystallised at −25° C. (yield: 84%, m.p. 76.0° C.).

Workup

  1. washThe organic phase is washed with water, sat. Na2S2O5 and sat. NaCl
  2. dry with materialdried over MgSO4
  3. filtrationfiltered through SiO2
  4. customThe solvent is removed under reduced pressure, petroleum ether
  5. additionis added to the oily residue
  6. customthe product is recrystallised at −25° C. (yield: 84%, m.p. 76.0° C.)

Sources & evidence

ORD record
ord-395f0dd895424302b3df39bb8bf8efa2
Source dataset
uspto-grants-2010_08
Patent number
US07786332B2

Reaction notes

Loading…