反应详情

A solution of methyl 4-hydroxy-3-isobutylbenzoate (0.80 g, 3.84 mmol), diphenylmethyl bromide (1.05 g, 4.25 mmol) and potassium carbonate (0.69 g, 4.99 mmol) in N,N-dimethylformamide (20 mL) was stirred at room temperature for 3 days. The reaction solution was poured into ice water, and the mixture was extracted with ethyl acetate. The extract was washed with aqueous citric acid solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography (ethyl acetate/hexane=3/97-15/85) to give the title compound (450 mg, yield 31%) as a colorless oil.

1. extractionthe mixture was extracted with ethyl acetate
2. washThe extract was washed with aqueous citric acid solution
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationconcentrated under reduced pressure