反应详情

To a solution of 3-[4-({[4′-(2-ethoxyethoxy)-2′,6′-dimethylbiphenyl-3-yl]methyl}amino)-2-fluorophenyl]propanoic acid (0.372 g, 0.800 mmol) in diethyl ether (5 mL) was added a solution of p-toluenesulfonic acid monohydrate (0.152 g, 0.800 mmol) in ethyl acetate (5 mL), and the resulting crystals were washed with ethyl acetate-diethyl ether to give the title compound as colorless crystals (0.456 g, yield 89%).

1. washthe resulting crystals were washed with ethyl acetate-diethyl ether