Hydrogen chloride-ethyl acetate → HCID 68720671, compound

HRID 508084Notes

Reaction equation

HRID 508084 reaction equation
[C:1]1([C:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:9]([CH2:18][C:19]3[CH:38]=[CH:37][C:22]([CH2:23][NH:24][C:25]4[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][C:33]([OH:35])=[O:34])=[C:27]([F:36])[CH:26]=4)=[CH:21][C:20]=3[O:39][CH:40]([CH3:42])[CH3:41])[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:43].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:43].[ClH:43].[C:1]1([C:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:9]([CH2:18][C:19]3[CH:38]=[CH:37][C:22]([CH2:23][NH:24][C:25]4[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][C:33]([OH:35])=[O:34])=[C:27]([F:36])[CH:26]=4)=[CH:21][C:20]=3[O:39][CH:40]([CH3:42])[CH3:41])[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 23157540HCID 23157540, compound

Product 1

HCID 68720671HCID 68720671, compoundYield 90.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

3-[4-({4-[(3,5-Diphenyl-1H-pyrazol-1-yl)methyl]-3-isopropoxybenzyl}amino)-2-fluorophenyl]propanoic acid (0.40 g, 0.71 mmol) was dissolved in ethyl acetate (4.0 mL), and 4 N hydrogen chloride/ethyl acetate solution (0.53 mL, 2.1 mmol) was added. The precipitated crystals were collected by filtration, washed with ethyl acetate and dried to give the title compound (0.41 g, yield 90%) as colorless crystals.

Workup

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed with ethyl acetate
  3. customdried

Sources & evidence

ORD record
ord-95d03c5928474f55885f045f0b0ce1a7
Source dataset
uspto-grants-2010_08
Patent number
US07786165B2

Reaction notes

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