反应详情

2.02 ml of methanesulfonyl chloride, followed by 3.65 ml of triethylamine were added, whilst ice-cooling, to a solution of 6.1 g of methyl 1-(t-butoxycarbonyl)-4-hydroxyprolinate [prepared as described in step (6) above] dissolved in 120 ml of dry tetrahydrofuran. The mixture was stirred first at 0° to 5° C. for 1 hour and then at room temperature for 1 hour, after which it was poured into an aqueous solution of sodium chloride and extracted with ethyl acetate. The extract was washed with an aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. The solvent was then removed by distillation under reduced pressure, to afford 8.13 g of the title compound as an oil.

1. additionwere added, whilst ice-
2. waitat room temperature for 1 hour
3. extractionextracted with ethyl acetate
4. washThe extract was washed with an aqueous solution of sodium chloride
5. dry with materialdried over anhydrous magnesium sulfate
6. customThe solvent was then removed by distillation under reduced pressure