Sodium Hydroxide → HCID 87549132, compound

HRID 508111Notes

Reaction equation

HRID 508111 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([NH:8][CH2:9][C:10]2[CH:11]=[C:12]([C:17]3[C:22]([CH3:23])=[CH:21][C:20]([O:24][CH2:25][C:26]4([OH:34])[CH2:31][CH2:30][S:29](=[O:33])(=[O:32])[CH2:28][CH2:27]4)=[CH:19][C:18]=3[CH3:35])[C:13]([CH3:16])=[CH:14][CH:15]=2)[CH:5]=[CH:4][C:3]=1[CH2:36][CH2:37][C:38]([OH:40])=[O:39].[OH-].[Na+].[Cl-].[Ca+2:44].[Cl-]>CO>[Ca+2:44].[F:1][C:2]1[CH:7]=[C:6]([NH:8][CH2:9][C:10]2[CH:11]=[C:12]([C:17]3[C:22]([CH3:23])=[CH:21][C:20]([O:24][CH2:25][C:26]4([OH:34])[CH2:27][CH2:28][S:29](=[O:33])(=[O:32])[CH2:30][CH2:31]4)=[CH:19][C:18]=3[CH3:35])[C:13]([CH3:16])=[CH:14][CH:15]=2)[CH:5]=[CH:4][C:3]=1[CH2:36][CH2:37][C:38]([O-:40])=[O:39].[F:1][C:2]1[CH:7]=[C:6]([NH:8][CH2:9][C:10]2[CH:11]=[C:12]([C:17]3[C:22]([CH3:23])=[CH:21][C:20]([O:24][CH2:25][C:26]4([OH:34])[CH2:27][CH2:28][S:29](=[O:33])(=[O:32])[CH2:30][CH2:31]4)=[CH:19][C:18]=3[CH3:35])[C:13]([CH3:16])=[CH:14][CH:15]=2)[CH:5]=[CH:4][C:3]=1[CH2:36][CH2:37][C:38]([O-:40])=[O:39]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 5284359Calcium ChlorideHCID 12002221HCID 12002221, compound

Product 1

HCID 87549132HCID 87549132, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 3-{2-fluoro-4-[({4′-[(4-hydroxy-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy]-2′,6,6′-trimethylbiphenyl-3-yl}methyl)amino]phenyl}propanoic acid (57.0 mg, 0.10 mmol) in methanol (1 mL) was added 1 M aqueous sodium hydroxide solution (0.10 mL). Successively, an aqueous solution of calcium chloride (6.2 mg, 0.05 mmol) was gradually added. The precipitated solid was collected by filtration, washed with water and vacuum dried to give the title compound (32.2 mg, yield 55%) as a colorless amorphous powder.

Workup

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with water and vacuum
  3. customdried

Sources & evidence

ORD record
ord-5343987a7b2a4d5e87e173c1d8d27311
Source dataset
uspto-grants-2010_08
Patent number
US07786165B2

Reaction notes

Loading…