反应详情

To a stirred solution of 4-((3,4-dichlorophenoxy)methyl)-2,5-difluorobenzonitrile (Preparation 23, 153 mg, 0.481 mmol) in DMSO (5 mL) was added potassium carbonate (133 mg, 0.962 mmol), followed by dropwise addition of 30% aqueous hydrogen peroxide solution (0.29 mL, 2.90 mmol). After 3 hours, the reaction was quenched with saturated aqueous potassium bisulphate solution (10 mL), and extracted with DCM (3×10 mL). The combined organics were washed with brine (2×10 mL), dried over magnesium sulphate, and concentrated in vacuo to afford the title compound as a white solid (60 mg, 38%).

1. customthe reaction was quenched with saturated aqueous potassium bisulphate solution (10 mL)
2. extractionextracted with DCM (3×10 mL)
3. washThe combined organics were washed with brine (2×10 mL)
4. dry with materialdried over magnesium sulphate
5. concentrationconcentrated in vacuo