反应详情

温度

100 °C

A 250 ml two-necked round-bottomed flask equipped with a magnetic bar, a thermometer and a reflux condenser is charged with DMF (50 ml), 4-chloro-3-trifluoromethyl-phenol (4.6 g), 2-chloro-3-methyl-5-nitro-pyridine (4.0 g) and potassium carbonate (6.4 g). The reaction mixture is heated at 100° C. for 2.5 hours. After cooling the mixture to room temperature it is then poured into water (200 ml). The mixture is then extracted with ethylacetate (2×40 ml). The combined organic layers are dried over sodium sulfate, filtered and the solvent is removed in vacuo to obtain 6.10 g of the compound as yellow solid (MP: 95-97° C.).

1. customA 250 ml two-necked round-bottomed flask equipped with a magnetic bar
2. temperatureAfter cooling the mixture to room temperature it
3. extractionThe mixture is then extracted with ethylacetate (2×40 ml)
4. dry with materialThe combined organic layers are dried over sodium sulfate
5. filtrationfiltered
6. customthe solvent is removed in vacuo