反应详情

温度

70 °C

Bromoethane (17 mL, 0.23 mmol) and K2CO3 (105 mg, 0.75 mmol) were added to a solution of N-ethylcarbamate-5-hydroxy-6-chloro-8-methyl-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole (44 mg, 0.15 mmol) in CH3CN (1.5 mL). The reaction was stirred overnight at 70° C., diluted with H2O and CH2Cl2, and filtered through an Extrelut column. The column was washed with CH2Cl2 and the filtrate was concentrated. The crude product was obtained without further purification. MS calculated for C17H22ClNO3+H: 324, observed: 324.

1. filtrationfiltered through an Extrelut column
2. washThe column was washed with CH2Cl2
3. concentrationthe filtrate was concentrated