Ammonia → 2-Chloro-6-iodobenzamide

HRID 508774ノート

反応式

HRID 508774 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([I:11])[C:3]=1[C:4](O)=[O:5].C(Cl)(=O)C(Cl)=O.[NH3:18].C1COCC1>C(Cl)Cl>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([I:11])[C:3]=1[C:4]([NH2:18])=[O:5]

参加物

6

反応物 4

HCID 222AmmoniaHCID 8028TetrahydrofuranHCID 65578Oxalyl chlorideHCID 133993742-Chloro-6-iodobenzoic acid

生成物 1

HCID 716509022-Chloro-6-iodobenzamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 2-chloro-6-iodobenzoic acid (2.7 g, 9.6 mmol), oxalyl chloride (1.4 g, 11.5 mmol), ammonia gas, THF (20 mL) and DCM (10 mL) to afford 2.3 g of the desired product. 1H NMR (300 MHz, DMSO d6): δ 7.11 (t, J=7.8 Hz, 1H), 7.49 (d, J=8.4 Hz, 1H), 7.73 (s, 1H), 7.80 (d, J=7.8 Hz, 1H), 8.00 (s, 1H); MS (m/z): 281.98 (M+H)+.

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-8f7f678354f14f3aa13045fd6d8195f9
出典データセット
uspto-grants-2015_08
特許番号
US09096545B2

反応ノート

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