Hydrogen Peroxide → HCID 90027995, compound

HRID 508902Notes

Reaction equation

[CH:1]([C:4]1[O:8][C:7]([C:9]2[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=2)=[N:6][N:5]=1)([CH3:3])[CH3:2].OO.C([O-])([O-])=[O:20].[K+].[K+]>>[CH:1]([C:4]1[O:8][C:7]([C:9]2[CH:16]=[CH:15][C:12]([C:13]([NH2:14])=[O:20])=[CH:11][CH:10]=2)=[N:6][N:5]=1)([CH3:3])[CH3:2]

Participants

Reactant 3

HCID 784Hydrogen Peroxide

HCID 11430Potassium Carbonate

HCID 900269264-[5-(Propan-2-yl)-1,3,4-oxadiazol-2-yl]benzonitrile

Product 1

HCID 90027995HCID 90027995, compoundYield 1,544.4%

Procedure

The title compound was prepared according to the procedure described in step1 of Intermediate-59 by using 4-(5-isopropyl-1,3,4-oxadiazol-2-yl)benzonitrile (0.500 g, 2.34 mmol), 50% H2O2 (5.0 mL), K2CO3 (0.097 g, 0.070 mmol) to afford 0.250 g of desired product. 1H NMR (400 MHz, DMSO d6): δ 1.3 (s, 3H), 1.35 (s, 3H), 3.33 (m, 1H), 7.56 (br s, 1H), 8.06 (s, 4H), 8.16 (br s, 1H); MS (m/z): 232.30 (M+H)+.

Workup

customThe title compound was prepared

Sources & evidence

ORD record: ord-4d40c1af43084c28a82a92a92e20a68d
Source dataset: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09096545B2

Reaction notes

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