Hydrochloric Acid → HCID 86658632, compound

HRID 509175Notes

Reaction equation

HRID 509175 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH:15]2[CH2:19][C:18]([O:20]C)=[C:17]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[CH:24][C:23]=3[CH3:30])[C:16]2=[O:31])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:32]>CC(C)=O>[ClH:32].[O:31]=[C:16]1[CH:17]([C:22]2[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[CH:24][C:23]=2[CH3:30])[C:18](=[O:20])[CH2:19][CH:15]1[CH2:14][CH:11]1[CH2:12][CH2:13][NH2+:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58481474HCID 58481474, compound

Product 1

HCID 86658632HCID 86658632, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 4-[4-methoxy-2-oxo-3-(2,4,6-trimethyl-phenyl)-cyclopent-3-enylmethyl]-piperidine-1-carboxylic acid tert-butyl ester (15.4 g, 36 mmol) in acetone (100 ml) is added 2N HCl (100 ml) and the reaction heated to reflux for 4 hours. The solvent is removed under reduced pressure to give 4-[2,4-dioxo-3-(2,4,6-trimethyl-phenyl)-cyclopentylmethyl]-piperidinium hydrochloride (12.58 g)

Workup

  1. temperaturethe reaction heated
  2. temperatureto reflux for 4 hours
  3. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-5aa1f7bb7af644fd901aec708ee5401b
Source dataset
uspto-grants-2015_08
Patent number
US09096560B2

Reaction notes

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