反应详情

Tert-butyl 4-(4-fluorophenyl)piperidine-1-carboxylate (46 mg, 0.165 mmol) was dissolved in MC (2 ml), followed by addition of trifluoroacetic acid (1 ml), and then the resulting mixture was stirred at room temperature for 4 hours. The resulting reaction liquid was neutralized by slow addition of a saturated aqueous NaHCO3 solution at 0° C., and then extracted with 5% MeOH/MC (10 ml×2). The organic layer was dried over anhydrous magnesium sulfate, followed by filtration, concentration, and vacuum drying, to obtain 22 mg of colorless oil (74%).

1. customThe resulting reaction liquid
2. extractionextracted with 5% MeOH/MC (10 ml×2)
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. filtrationfollowed by filtration, concentration, and vacuum
5. customdrying