反应详情

To a solution of methyl 1-(difluoromethyl)-6-oxo-1,6-dihydropyridine-3-carboxylate (0.500 g, 2.461 mmol) in MeOH (12 mL) and water (4 mL) was added lithium hydroxide hydrate (0.207 g, 4.92 mmol, Aldrich). The resulting mixture was then stirred at room temperature for 4 h. Solvent (MeOH) was removed in vacuok, and the remaining aqueous solution was adjusted to pH=5-6 by addition of concentrated HCl. The mixture was then extracted with EtOAc (3×10 mL). The combined organic layers were dried (MgSO4), and the solvent removed to give the title compound as a yellow solid. MS (ESI, positive ion) m/z: 190 (M+H).

1. customSolvent (MeOH) was removed in vacuok
2. additionthe remaining aqueous solution was adjusted to pH=5-6 by addition of concentrated HCl
3. extractionThe mixture was then extracted with EtOAc (3×10 mL)
4. dry with materialThe combined organic layers were dried (MgSO4)
5. customthe solvent removed