Potassium tert-butoxide → HCID 72188192, compound

HRID 509443Notes

Reaction equation

HRID 509443 reaction equation
S([C:5]1C=[CH:10][C:8](C)=[CH:7][CH:6]=1)(O)(=O)=O.[CH3:12][N:13]([CH3:30])[C:14]([C:16]1[NH:17][C:18]2[C:23]([CH:24]=1)=[CH:22][C:21]([NH:25][C:26]([NH2:28])=[NH:27])=[CH:20][C:19]=2[Br:29])=[O:15].CC(C)([O-])C.[K+]>CN(C)C=O>[CH3:12][N:13]([CH3:30])[C:14]([C:16]1[NH:17][C:18]2[C:23]([CH:24]=1)=[CH:22][C:21]([NH:25][C:26]1[N:28]=[C:7]([C:8]3[N:27]=[CH:26][N:25]([CH3:21])[CH:10]=3)[CH:6]=[CH:5][N:27]=1)=[CH:20][C:19]=2[Br:29])=[O:15]

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 178484408HCID 178484408, compound

Product 1

HCID 72188192HCID 72188192, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
150 °C

Procedure

A mixture of 1.6 g 4.6, 2.2 g 7.12 and 2.5 g potassium tert-butoxide in 30 ml N,N-dimethylformamide was stirred at 150° C. for 1.5 h under microwave irradiation. The reaction mixture was concentrated in vacuo and the resulting residue was purified by flash chromatography (dichloromethane/methanol 100:0→90:10) to give intermediate 10.1/Example 15.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe resulting residue was purified by flash chromatography (dichloromethane/methanol 100:0→90:10)
  3. customto give intermediate 10.1/Example 15

Sources & evidence

ORD record
ord-6e5f3df3a04c4845a0c3b7ed0cf06111
Source dataset
uspto-grants-2015_08
Patent number
US09096579B2

Reaction notes

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