Hydrochloric Acid → HCID 117856224, compound

HRID 509900Notes

Reaction equation

HRID 509900 reaction equation
FC(F)(F)C([O-])=O.C(OC([NH:15][CH:16]1[CH2:21][CH2:20][CH2:19][N+:18]([CH2:35][CH2:36][CH2:37][C:38]2[CH:43]=[CH:42][C:41]([C:44]([O:46][CH3:47])=[O:45])=[CH:40][CH:39]=2)([CH2:22][CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]([O:33][CH3:34])=[O:32])=[CH:27][CH:26]=2)[CH2:17]1)=O)(C)(C)C.[ClH:48]>O1CCOCC1>[ClH:48].[Cl-:48].[NH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][N+:18]([CH2:35][CH2:36][CH2:37][C:38]2[CH:39]=[CH:40][C:41]([C:44]([O:46][CH3:47])=[O:45])=[CH:42][CH:43]=2)([CH2:22][CH2:23][CH2:24][C:25]2[CH:26]=[CH:27][C:28]([C:31]([O:33][CH3:34])=[O:32])=[CH:29][CH:30]=2)[CH2:17]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117856126HCID 117856126, compound

Product 1

HCID 117856224HCID 117856224, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

3-tert-butoxycarbonylamino-1,1-bis-[3-(4-methoxycarbonyl-phenyl)-propyl]-piperidinium trifluoroacetate (200 mg, 0.3 mmol) is dissolved in dioxane (10 ml), a 4 M solution of HCl in dioxane (10 ml, 40 mmol) is added, stirred at room temperature overnight and concentrated in vacuo. LC (method F): tR=1.49 min; Mass spectrum (ESI+): m/z=453 [M]+.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-4e733335478441f491025153ca7fe589
Source dataset
uspto-grants-2015_08
Patent number
US09096548B2

Reaction notes

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