Hydrochloric Acid → HCID 117856407, compound

HRID 509902Notes

Reaction equation

HRID 509902 reaction equation
FC(F)(F)C([O-])=O.C(OC([NH:15][CH:16]1[CH2:21][CH2:20][CH2:19][N+:18]([CH2:33][CH2:34][CH2:35][C:36]2[CH:41]=[CH:40][C:39]([C:42]([O:44][CH3:45])=[O:43])=[CH:38][CH:37]=2)([CH2:22][CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=2)[CH2:17]1)=O)(C)(C)C.[ClH:46]>O1CCOCC1>[ClH:46].[Cl-:46].[NH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][N+:18]([CH2:33][CH2:34][CH2:35][C:36]2[CH:41]=[CH:40][C:39]([C:42]([O:44][CH3:45])=[O:43])=[CH:38][CH:37]=2)([CH2:22][CH2:23][CH2:24][C:25]2[CH:26]=[CH:27][C:28]([O:31][CH3:32])=[CH:29][CH:30]=2)[CH2:17]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117856665HCID 117856665, compound

Product 1

HCID 117856407HCID 117856407, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

3-tert-Butoxycarbonylamino-1-[3-(4-methoxycarbonyl-phenyl)-propyl]-1-[3-(4-methoxy-phenyl)propyl]-piperidinium trifluoroacetate (525 mg, 0.82 mmol) is dissolved in dioxane (10 ml), a 4 M solution of HCl in dioxane (10 ml, 40 mmol) is added, stirred at room temperature for 2 h and concentrated in vacuo. LC (method 004_CC_ZQ7): tR=1.80 min; Mass spectrum (ESI+): m/z=425 [M]+.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-74171bd6393a4b69b511959b30c28687
Source dataset
uspto-grants-2015_08
Patent number
US09096548B2

Reaction notes

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